When there is a blockage or narrowing within the arteries, it's harder for blood to flow normally to the heart which causes Coronary Artery Disease. It's Singapore's most common heart disease that can lead to chest pains or shortness of breath (angina) during exertion or stress, heart attack and heart failure. One of the main causing factors is the gradual build-up of fatty deposits within the wall of the arteries called plaques. Over a long time, these fatty despoits might clog the blood flow to the heart muscle.